General Information

  • ID:  hor006850
  • Uniprot ID:  O60565??26-184)
  • Protein name:  Gremlin-1
  • Gene name:  TSHB
  • Organism:  Homo sapiens
  • Family:  DAN family
  • Source:  Human
  • Expression:  Highly expressed in small intestine; fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
  • GO MF:  NA
  • GO BP:  GO:0016015 morphogen activity; GO:0030297 transmembrane receptor protein tyrosine kinase activator activity; GO:0048018 receptor ligand activity; GO:0042803 protein homodimerization activity; GO:0005125 cytokine activity; GO:0036122 BMP binding; GO:0043184 vascular endothelial growth factor receptor 2 binding
  • GO CC:  GO:0007267 cell-cell signaling; GO:0045892 negative regulation of DNA-templated transcription; GO:0002042 cell migration involved in sprouting angiogenesis; GO:0060379 cardiac muscle cell myoblast differentiation; GO:0055007 cardiac muscle cell differentiation; GO:0045668 negative regulation of osteoblast differentiation; GO:0000902 cell morphogenesis; GO:0009887 animal organ morphogenesis; GO:0090027 negative regulation of monocyte chemotaxis; GO:0048263 determination of dorsal identity; GO:0033689 negative regulation of osteoblast proliferation; GO:0030326 embryonic limb morphogenesis; GO:0060173 limb development; GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis; GO:0043066 negative regulation of apoptotic process; GO:0030514 negative regulation of BMP signaling pathway; GO:0030502 negative regulation of bone mineralization; GO:1900158 negative regulation of bone mineralization involved in bone maturation; GO:0046851 negative regulation of bone re

Sequence Information

  • Sequence:  KKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
  • Length:  159
  • Propeptide:  MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
  • Signal peptide:  MSRTAYTVGALLLLLGTLLPAAEG
  • Modification:  T24 Phosphotyrosine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA